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The Role of DDR and PARP inhibition (PARPi) in Oncology – BluePrints

The Role of DDR and PARP inhibition (PARPi) in Oncology – BluePrints

Dr. Violeta Serra, Prof. Jonathan A. Ledermann, Prof. Eric Pujade-Lauraine, Prof. Simon Boulton, Dr. Mark J. O'Connor, Prof. Charlie Gourley, Dr. Judith Balmaña, Prof. Sibylle Loibl

DDR and PARPi BluePrint documents have been developed under the guidance of a Steering Committee with expertise in the field of DDR and PARP inhibition (PARPi).

Portrait of Violeta Serra
Dr. Violeta Serra

Senior Scientist

Vall d'Hebron Institute of Oncology

Spain

Portrait of Jonathan A. Ledermann
Prof. Jonathan A. Ledermann

Medical Oncologist

UCL Cancer Institute

United Kingdom (UK)

Portrait of Eric Pujade-Lauraine
Prof. Eric Pujade-Lauraine

Gynaecologic Oncologist

Hôpital Hôtel-Dieu

France

Portrait of Simon Boulton
Prof. Simon Boulton

Senior Scientist

Francis Crick Institute

United Kingdom (UK)

Portrait of Mark J. O'Connor
Dr. Mark J. O’Connor

Senior Scientist

AstraZeneca

United Kingdom (UK)

Portrait of Charlie Gourley
Prof. Charlie Gourley

Medical Oncologist

CRUK Edinburgh Centre, Nicola Murray Centre for Ovarian Cancer Re...

United Kingdom (UK)

Portrait of Judith Balmaña
Dr. Judith Balmaña

Medical Oncologist

Vall d'Hebron University Hospital

Spain

Portrait of Sibylle Loibl
Prof. Sibylle Loibl

Medical Oncologist

German Breast Group GmbH

Germany

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time | open min | Sep 2021

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These BluePrints are a reference guide to key aspects of PARPi and DDR and their role in oncology.

A variety of topics are covered, including the role of DDR in oncology, synthetic lethality, use of PARPi in oncology, efficacy and safety of currently approved PARP inhibitors, and the role of combination therapy with PARPi.

 

 

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