Interactive Patient Case Study Demo
Interactive Patient Case Study Demo
Joanne Pearson, Prof. Dr. Uwe Zeymer, Prof. Dr. Zuzana Motovska
Listen to the interview where Experts discuss cases of a patient preparing for lumbar surgery and a pregnant patient with questions about delivery and pain relief.
Joanne Pearson
Gynaecologic Oncology
University Hospital Southampton NHS Foundation Trust
United Kingdom (UK)
Jo Pearson, RN has been a cancer nurse for over 15 years, beginning her career in SACTadministration in a busy cancer centre before developing an interest in supporting women whohave a gynaecologicalcancer diagnosis. Jo became a Macmillan Gynae/Oncology Clinical NurseSpecialist (CNS) 6 years ago and enjoys supporting women and their families from pre-diagnosisthrough their treatment pathways.Jo has a special interest in cancer genomics having recently completed a course with Guy’s andSt Thomas’,and has established a weekly BRCA consenting and holistic needs clinic. Jo haspresented at national and international forums and has contributed to several publications inrelation to nurse-led PARP clinics and other service development initiatives. Jo is a mother of 2who enjoys live music and travelling.
Joanne Pearson has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
Prof. Dr. Uwe Zeymer
Cardiologist
Heart Center Ludwigshafen
Germany
Prof. Dr. Uwe Zeymer is Head of Interventional Cardiology at the Heart Center Ludwigshafen, Department of Cardiology, Germany. He is Vice-Director of the Institut für Herzinfarktforschung Ludwigshafen. He has been board certified in internal medicine, cardiology, interventional cardiology and intensive care medicine. After his graduation from Medical School at the Universities of Munich and Marburg in 1985, Dr Zeymer gained experience as a resident, fellow and attendee in the Department of Cardiology, Municipal Hospital, Kassel, and as a clinical research fellow in the Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, USA. He is full Professor of Medicine at the University of Göttingen. Dr. Zeymer is or has chaired or been a member of the Steering Committee numerous trials in patients with acute coronary syndromes, antithrombotic therapies and anticoagulants. In addition, he has been chair or member of the Steering committee of several international registries in interventional cardiology, treatment of hypertension, anticoagulation for atrial fibrillation and acute coronary syndromes. Dr. Zeymer has authored and co-authored over 450 scientific papers on cardiovascular disease in journals such as the New England Journal of Medicine, Lancet, JAMA, European Heart Journal, Circulation and Journal of the American College of Cardiology. Dr. Zeymer has been the Chair of the Scientific Committee of the Acute Cardiovascular Care Association of the ESC, the Chair of the Working Group of Thrombosis of the German Cardiac Society and the Chair of the Working for Quality Insurance and Registries of the German Cardiac Society. He was President of the annual Autumn Meeting of the German Cardiac Society 2013. He is currently chairing the ongoing STEMI-Registry of the EORP of the ESC.
Prof. Dr. Uwe Zeymer has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
Prof. Dr. Zuzana Motovska
Cardiologist
Charles University
Czech Republic
Present Position and Address Head of the Division of Acute Cardiology Deputy Head of Department for the Research Cardiology Department Cardiocenter Third Faculty of Medicine, Charles University University Hospital Kralovské Vinohrady Prague, Czech Republic Post Graduate Degrees Appointed as Professor of Internal Medicine at the Charles University, Prague, Czech Republic European Society of Cardiology Activities Councilor of the ESC Board 2018-2020 Member of Working group on Thrombosis Member of Acute Cardiovascular Care Association National coordinator of the ACS-STEMI Registry EORP Fellowships / Honours Fellow of European Society of Cardiology (since 2007) Award given by the Ministry of Education, Youth and Sports of Czech Republic for extraordinary results in research, experimental development and innovation – awarded in the year 2015 Major Research Interest Acute coronary syndromes Acute cardiac care Antithrombotic therapy Cardiovascular disease in women Cardiogenic shock Major Scientific Activities Principal investigator (design, leadership, coordination): Multicenter randomized PRAGUE 8 study Multicenter randomized PRAGUE 18 study Multicenter double-blind randomized DAPT-SCHOCK-AMI (PRAGUE 23) study (ongoing)
Prof. Dr. Zuzana Motovska has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
Interactive Video Example
Video | 60 min | Jun 2021
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This programme was made for you: your opinion matters
Share your feedback in just 4 clicks and help us to continue to create the content you need.
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Welcome
Michael Mazzeffi (MM)
Hello everyone, my name is Michael Mazzeffi, I’m an anaesthesiologist and an intensive care physician. It’s a pleasure to be here with you today. I’m here with Dr Boban who will introduce herself.
Ana Boban (AB)
Hello everybody my name is Ana Boban, I’m working in the haemophilia centre in Zagreb, Croatia.
MM
We’re going to be speaking with you today about von Willebrand disease and specifically we’re going to talk about surgical patients with von Willebrand disease. We’re going to talk about two cases and we hope these will illustrate some important principles of patient management.
Case 1 – surgery in a patient with von Willebrand disease
MM
We have a 42-year-old man who presents for spine surgery, lumbar spine surgery. Interestingly, or of note, this patient has a history of von Willebrand disease type 2a and he has a history of some excessive bleeding with a prior dental procedure. You see the patient’s laboratory values here and importantly we have the patient’s von Willebrand factor antigen level and the von Willebrand factor ristocetin cofactor activity.
Now I want to ask Dr Boban, let’s say this patient comes to see you before their surgery, about a week ahead of time so we have some time for planning, what laboratory tests would you send for the patient or would be important to consider? And how do you think we should treat this patient during the time around the time of surgery?
AB
This patient has an increased risk of bleeding during the surgery. This is obviously high-risk surgery, therefore we want to make sure that haemostasis at that time is perfect for this patient. We have a couple of options for treating patients with von Willebrand disease: DDAVP and von Willebrand factor concentrate. Regarding the low levels of available factor in this patient and the high-risk surgery I would go with von Willebrand factor concentrate to treat him.
To know how how to dose the treatment I would have to do another test for von Willebrand factor activity and factor VIII. If it’s possible, I would like to have data on how he responds to the treatment with von Willebrand factor concentrate, the half-life, so I can tailor the treatment. We want to make sure that the von Willebrand factor activity is more than 50%, but also avoid too high activity of factor VIII, to not increase the risk of thrombosis during the surgery.
MM
That’s very helpful. I can say as an anaesthesiologist it would be great if the haematologist that I were working with gave me some recommendations like that: a dose of von Willebrand factor concentrate and then how to monitor for the efficacy of that treatment.
Let me also ask you: would you use or recommend some other treatments, for example the use of antifibrinolytic drugs around the time of surgery? Is that something that might be helpful?
AB
Yes, antifibrinolytics are very helpful in patients with von Willebrand disease. Actually, they have a low risk of side effects. So yes, I would definitely include it. But I would also try to talk to the neurosurgeon to understand what kind of surgery is going to be performed and what is the risk of bleeding. I think the multi-disciplinary approach here and close collaboration between anaesthesiologist, neurosurgeon and haematologist is crucial.
Also, I would like to point out that good communication with the coagulation laboratory is crucial. Sometimes you will need to have results of von Willebrand factor levels and factor VIII levels quickly, within one or two hours. This sometimes has to be discussed in advance, so that the coagulation laboratory is expecting these samples to come to the laboratory and to be processed quickly.
What is the view of anaesthesiologist in this? Do you think you should have a good collaboration with haematologists during the operation or do you think that it can be all be settled in advance?
MM
Ideally, I think you have a good working relationship with the haematologist. Of course, we have a plan ahead of time and we can execute that plan but there always are unexpected events. So, it’s nice to be able to contact your colleague, the haematologist, in case there’s a little more bleeding than anticipated. Perhaps we need a second dose of von Willebrand factor concentrate or maybe a lower second dose? I think that would be the best kind of situation.
AB
I agree with you completely.
Case 2 –von Willebrand disease and delivery
AB
We have another patient: a 22-year-old lady who is pregnant, now at 32 weeks of has pregnancy. She has von Willebrand disease that was diagnosed when she was a child, because she has positive family history. Actually, during her lifetime she didn’t have many bleeding episodes. She has extended menstrual bleeding and couple of epistaxis but no other spontaneous bleedings. Now she is coming to the clinic and asking about delivery and anaesthesia. What would you recommend to her doctor Mazzeffi?
MM
My main point would be that with appropriate planning it is possible to safely have an epidural placed for labour analgesia or a spinal if needed for caesarean section. But appropriate planning is needed. If appropriate planning is in place, there’s probably minimal increased risk. So I think it is possible, but it will require measurement of von Willebrand factor levels, perhaps treatment. But it can be done safely and that’s great for women who want to have some pain relief during their delivery.
AB
That’s a very good answer and very positive for our patients with von Willebrand disease. We can tell them that delivery is actually something that is safe and, if managed properly, there is no increased risk of excessive bleeding.
Just to point out that for patients with von Willebrand disease the activity of von Willebrand factor rises throughout the pregnancy. For some patients the level is sufficient for epidural anaesthesia but for some patients it’s not enough. So, we have to know exactly what the level of von Willebrand factor is at the time of the delivery, to be able to add some haemostatic treatment if needed.
What do you think about patients after the delivery, do they have increased risk of bleeding at that period?
MM
I think that’s the period where we really have to be careful. At the time of the delivery everyone is very vigilant, paying close attention, but there is bleeding risk in the days following, as you know. I think we have to continue to carefully monitor the patient for at least a week or so after the surgery, to make sure we don’t miss a low level of von Willebrand factor and have excessive bleeding.
AB
We had a lot of patients that actually did fine throughout delivery and then afterwards had a significant decrease in von Willebrand factor activity and then needed treatment a couple of days after the delivery.
Key takeaways
AB
Can you please just sum up what you think are the most important issues regarding the patients with von Willebrand disease and spinal operation.
MM
My main takeaway points are:
- Planning is very important in advance
- A collaborative approach with good communication in case we have some excessive bleeding that we didn’t anticipate
- With good planning and appropriate treatment, we should be able to mitigate the risk and not have excessive bleeding in these kinds of cases
AB
I feel the same for the pregnant patients with von Willebrand disease. The most important things are:
- to plan ahead
- to have a multidisciplinary approach
- to have these procedures done in a facility that has a good haemostasis department, a good coagulation laboratory and also specialists of gynaecology and surgery
Thank you Dr Mazzeffi for this very nice interview with you, I enjoyed it.
MM
Same, I enjoyed it very much. Thank you.
HEMOSTASIS CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Takeda.
Other programmes of interest
Other programmes developed by Joanne Pearson
Joanne Pearson
Gynaecologic Oncology
University Hospital Southampton NHS Foundation Trust
United Kingdom (UK)